TLK1 Rabbit Polyclonal Antibody

Description

EnkiLife offers the TLK1 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for ICC/IF,ELISA application. Alternative Names of Immunogen: TLK1; KIAA0137; Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: ICC/IF 1:200-1:1000,ELISA 1:5000-1:10000 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHK1. function:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. similarity:Belongs to the protein kinase superfamily. similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. similarity:Contains 1 protein kinase domain. subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B. tissue specificity:Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.