TLR3 Knockout Immortalized Mouse Dendritic Cell Line

Description

As messengers bridging the innate and adaptive immune system, the conventional tissue-resident DC cDC acts as sentinels in secondary lymphoid organs and other tissues for antigen capture and presentation. The MutuDCTlr3-/- cell line is an immortalized splenic CD8alpha subset CD11chigh,B220-,DEC205 ,CD24high,CD11b- of conventional dendritic cells derived from the TLR3 knockout CD11c:SV40LgT transgenic mice . The MutuDCTlr3-/- cell line retains response to TLR ligands such as CpG TLR9-L and to a lesser extent LPS TLR4-L but not PolyIC TLR3-L . Like the Wild-type MutuDC cells Cat. No. T0528 , these cells are capable of presenting antigen in the context of both MHC-I and MHC-II, including direct antigen presentation and cross-presentation of cell-associated antigens. Together with TLR9 knockout Cat. No. T3035 and Ifnar1 knockout Cat. No. T3036 MutuDC, these dendritic cell lines provide a powerful tool in vaccine science and immunotherapy, particularly in strategizing target antigens to CD8alpha subset.