TLR7/8 agonist 13

Description

TLR7/8 agonist 13 is an orally active dual agonist of TLR7 lowest effective concentrations LEC hTLR7 = 1.6 ?M and TLR8 LEC hTLR8 = 1.6 ?M . TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells hPBMCs LEC hPBMC = 0.5 ?M . TLR7/8 agonist 13 induces endogenous IFN?, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFN?, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus.