TM-233

Description

TM-233 is an inhibitor of the JAK/STAT and NF-?B signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-?B from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-?B expression. TM-233 shows potential in overcoming Bortezomib HY-10227 resistance and can be applied in research related to multiple myeloma.