GENERAL CATALOGUE
TMPA
HY-18555 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-18555
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Catalog No: HY-18555
CAS No: 1258275-73-8
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPK?. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD restimulation-induced cell death in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation.