TMPO

Description

TMPO 3,3,5,5-Tetramethyl-1-pyrroline 1-oxide is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM MPS-induced to 30.7 mM Etoposide-induced for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress e.g., decreasing peroxide levels, maintaining glutathione content and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes.