GENERAL CATALOGUE
TMX-2138
HY-164906 · 50 mg
MedChemExpress · Cat: HY-164906
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Catalog No: HY-164906
CAS No: 2488892-07-3
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer Pink: CDKs ligand HY-151071 ; Blue: E3 ligase CRBN ligand HY-14658 ; Black: linker HY-W008352 .
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