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TNF-?-IN-18
GENERAL CATALOGUE

TNF-?-IN-18

HY-164102 · 5 mg

MedChemExpress · Cat: HY-164102

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Catalog No: HY-164102
CAS No: 1272322-42-5
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress

Description

TNF-?-IN-18 Compound 61 is an inhibitor for TNF-? IC50 of 1.8 ?M , that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-?-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 ?M. TNF-?-IN-18 ameliorates the TNF- or Lipopolysaccharide HY-D1056 -induced sepsis in mouse models. TNF-?-IN-18 protects mice from rheumatoid arthritis.

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