

HY-164102 · 5 mg
MedChemExpress · Cat: HY-164102
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medchemexpress.com/tnf-%CE%B1-in-18.htmlDescription
TNF-?-IN-18 Compound 61 is an inhibitor for TNF-? IC50 of 1.8 ?M , that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-?-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 ?M. TNF-?-IN-18 ameliorates the TNF- or Lipopolysaccharide HY-D1056 -induced sepsis in mouse models. TNF-?-IN-18 protects mice from rheumatoid arthritis.