GENERAL CATALOGUE
TNG348
HY-160700 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-160700
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medchemexpress.com/tng348.htmlCatalog No: HY-160700
CAS No: 2839740-79-1
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects HRD .
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