GENERAL CATALOGUE
TNKS-2-IN-3
HY-172747 · 50 mg
MedChemExpress · Cat: HY-172747
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medchemexpress.com/tnks-2-in-3.html
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Catalog No: HY-172747
CAS No: 2580941-64-4
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
TNKS-2-IN-3 Compound 5 is a selective competitive tankyrase 2 TNKS2 inhibitor with an IC50 value of 0.3 nM, showing over 20-fold selectivity over TNKS1 and more than 100-fold selectivity over PARP1/2. TNKS-2-IN-3 stabilizes axin and suppresses the Wnt/?-catenin pathway by inhibiting TNKS2-mediated ADP-ribosylation, exhibiting antiproliferative activity in colorectal cancer cells. TNKS-2-IN-3 is proming for rasearch of solid tumors with aberrant Wnt pathway activation, such as colorectal cancer.