GENERAL CATALOGUE
TNP
HY-110079 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-110079
₹110 – ₹160 approx.This price excludes freight and taxes. Please RFQ to get the final price.
Reach 3+ verified distributors
Manufacturer product page
medchemexpress.com/IP3K_Inhibitor.html
Sponsored
Catalog No: HY-110079
CAS No: 519178-28-0
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 ?M and 10.2 ?M for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization 1 2 3 .
More from MedChemExpress
(R)-Trolox (Standard)
HY-101445AR
Metabolic Enzyme Protease
Propentofylline-d6
HY-107203S
Metabolic Enzyme Protease
PTP1B-IN-2
HY-100462
Metabolic Enzyme Protease
Stearic acid-PEG-Mal, MW 2000
HY-W440950
Metabolic Enzyme Protease
Enazadrem phosphate
HY-U00024A
Metabolic Enzyme Protease
1,2-Dihexanoyl-sn-glycero-3-phosphocholine
HY-W127457
Metabolic Enzyme Protease
(R)-KT109
HY-126031
Metabolic Enzyme Protease
?-Glucosidase-IN-31
HY-149409
Metabolic Enzyme Protease