GENERAL CATALOGUE
Tomivosertib
HY-100022 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-100022
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Catalog No: HY-100022
CAS No: 1849590-01-7
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Tomivosertib eFT508 is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib eFT508 treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 IC50=2-16 nM in tumor cell lines. Tomivosertib eFT508 also dramatically downregulates PD-L1 protein abundance.
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