GENERAL CATALOGUE
Tomivosertib hydrochloride
HY-100022A · 50 mg
MedChemExpress · Cat: HY-100022A
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medchemexpress.com/tomivosertib-hydrochloride.htmlCatalog No: HY-100022A
CAS No: 1849590-02-8
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 IC50=2-16 nM in tumor cell lines. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance.
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