Top3b CRISPR Knockout 17CL-1 Stable Cell Line (Top3b-KO4 17CL-1)

Description

The Top3b CRISPR Knockout 17CL-1 Stable Cell Line T3605 is another variant engineered by CRISPR-Cas9 to disrupt the Topoisomerase 3b TOP3B gene. This cell line focuses on studying the effects of TOP3B inactivation on mRNA translation and turnover, with particular emphasis on its interaction with TDRD3 and its role in neurogenesis and synaptic plasticity. The knockout is targeted to a different region of the TOP3B gene compared to other variants, offering insights into the specific functional domains of TOP3B. It is an excellent model for exploring the implications of TOP3B loss in neurological diseases and RNA-based therapies. Complete list of cell lines from this panel: Cat. T3603 - Tdrd3 CRISPR Knockout 17CL-1 Stable Cell Line Tdrd3-KO1 17CL-1 Cat. T3604 - Top3b CRISPR Knockout 17CL-1 Stable Cell Line Top3b-KO2 17CL-1 Cat. T3605 - Top3b CRISPR Knockout 17CL-1 Stable Cell Line Top3b-KO4 17CL-1