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Topo I/II-IN-2
GENERAL CATALOGUE

Topo I/II-IN-2

HY-170912 · 50 mg

MedChemExpress · Cat: HY-170912

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Catalog No: HY-170912
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

Topo I/II-IN-2 Compound 3g is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 ?M and 1.42 ?M, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC small cell lung cancer cell proliferation, invasion, and migration in vitro. .

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