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TOPOI/PARP-1-IN-1
GENERAL CATALOGUE

TOPOI/PARP-1-IN-1

HY-158138 · 50 mg

MedChemExpress · Cat: HY-158138

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Catalog No: HY-158138
CAS No: 2948352-16-5
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

TOPOI/PARP-1-IN-1 Compound B6 is an orally active, low cytotoxic TOPOI/PARP dual inhibitor with an IC50 value of 0.09 ?M for PARP1. TOPOI/PARP-1-IN-1 can effectively inhibit the proliferation and migration of cancer cells. TOPOI/PARP-1-IN-1 also causes cell cycle arrest in the G0/G1 phase and induces apoptosis. The tumor growth inhibition rate TGI of TOPOI/PARP-1-IN-1 in mice is 75.4 %.

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