GENERAL CATALOGUE
TP0463518
HY-112144 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-112144
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Catalog No: HY-112144
CAS No: 1558021-37-6
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 IC50=18 nM , PHD2 Ki=5.3 nM , and PHD3 IC50=63 nM , and targets monkey PHD2 with an IC50 of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIF?, thereby upregulating erythropoietin EPO expression and enhancing intestinal iron absorption such as increased DMT-1 and dCYTb expression , improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia.
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