TP1L

Description

TP1L is a potent and selective T-cell protein tyrosine phosphatase TC-PTP PROTAC degrader, with a DC50 value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-? signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. Pink: TC-PTP ligand: HY-138964 , Blue: E3 ligase CRBN Ligand HY-A0003 , Black: Linker: HY-140002 .