GENERAL CATALOGUE
TQ05310
HY-164542 · 50 mg
MedChemExpress · Cat: HY-164542
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Catalog No: HY-164542
CAS No: 2071196-10-4
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q IC50=136.9 nM and IDH2-R172K IC50=37.9 nM mutants. TQ05310 inhibits the production of 2-hydroxyglutarate 2-HG and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia.
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