TRAIL R2/DR5/TNFRSF10B, His, Mouse

Description

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL APO2 ligand . DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex DISC performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases aspartate-specific cysteine proteases mediating apoptosis.