GENERAL CATALOGUE
Trans-Abacavir Dihydrochloride
CS-BI-00051 · 10 mg
Clearsynth · Cat: CS-BI-00051
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Catalog No: CS-BI-00051
CAS No: 267668-71-3
Category: Abacavir
Pack Size: 10 mg
Brand: Clearsynth
Description
trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir is a carbocyclic 2?-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection 1 . Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate CBV-TP , which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA 2 . Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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