GENERAL CATALOGUE
TRAP-1
HY-169369 · 1 mg
MedChemExpress · Cat: HY-169369
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Catalog No: HY-169369
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
TRAP-1 XJZ-06-462 is a selective p53Y220C transcriptional activator. TRAP-1 can engage p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 p53Y220C cells than in A549 cells p53WT , with IC50 values of 0.531 ?M and 3.94 ?M, respectively. TRAP-1 can be used for the study of p53Y220C-bearing cancer.
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