TRAP-14 amide

Description

TRAP-14 amide, a proteinase activated receptor PAR -activating peptide, is a PAR agonist with an EC50 of 24 ?M. TRAP-14 amide significantly induces platelet aggregation through ADP- and MMP-2-dependent pathways with Aspirin HY-14654 -insensitivity. TRAP-14 amide also effectively increases glycoprotein GP Ib and GPIIb/IIIa surface expression and ADP release.