TRBP-IN-1

Description

TRBP-IN-1 Compound 13j is an orally active TAR RNA binding protein 2 TRBP inhibitor IC50: 12.72 ?M . TRBP-IN-1 has significant anti-hepatocellular carcinoma HCC activity and can inhibit the proliferation and metastasis of HCC cells HCCLM3 cells IC50: 18.96 ?M ; SK-Hep-1 cells IC50: 16.45 ?M . TRBP-IN-1 regulates miRNA biogenesis and inhibits oncogenic miRNA expression by targeting TRBP. TRBP-IN-1 induces apoptosis and pyroptosis in HCC cells by inhibiting the level of miRNA. TRBP-IN-1 can be used for targeted therapy research of HCC.