TREM2 hFc Chimera, Human

Description

TREM-2 Triggering Receptor Expressed on Myeloid cells-2 is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid aa extracellular domain ECD with one V-type Ig-like domain, a 21 aa transmembrane TM domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding PubMed:10799849 . Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.