GENERAL CATALOGUE
TRF1-TIN2 PPI-IN-1
HY-172662 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-172662
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Manufacturer product page
medchemexpress.com/trf1-tin2-interaction-in-1.htmlCatalog No: HY-172662
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
TRF1-TIN2 PPI-IN-1 Compound 40 is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 PPI-IN-1 binds to the TRFH domain of TRF1 KD = 29 ?M and competitively inhibits the binding of the TIN2 peptide IC50 = 67 ?M . TRF1-TIN2 PPI-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 PPI-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers.
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