Trimebutine (3-TCBS)

Description

Trimebutine 3-TCBS GIC-1001 is an innovative formulation designed to release hydrogen sulfide H2S in vivo. This compound combines trimebutine with an H2S-releasing antagonist phenyl 3-thiocarbamate and exhibits enhanced anti-nociceptive effects in a mouse colonic distension model, superior to conventional trimebutine. GIC-1001 can reduce visceral pain and discomfort associated with lumen distension in a dose-dependent manner, showing potential superiority.