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Trimetrexate
GENERAL CATALOGUE

Trimetrexate

HY-10373 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-10373

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medchemexpress.com/Trimetrexate.html
Catalog No: HY-10373
CAS No: 52128-35-5
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Trimetrexate CI-898 is an antibiotic, also a potent and orally active dihydrofolate reductase DHFR inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia PCP and cancer.

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