

HY-10373B · 50 mg
MedChemExpress · Cat: HY-10373B
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medchemexpress.com/trimetrexate-isethionate.htmlDescription
Trimetrexate CI-898 isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase DHFR inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia PCP and cancer.







