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Trimetrexate isethionate
GENERAL CATALOGUE

Trimetrexate isethionate

HY-10373B · 50 mg

MedChemExpress · Cat: HY-10373B

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Catalog No: HY-10373B
CAS No: 82935-04-4
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress

Description

Trimetrexate CI-898 isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase DHFR inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia PCP and cancer.

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