GENERAL CATALOGUE
TRV-120027 TFA
HY-P2141A · 1 mg
MedChemExpress · Cat: HY-P2141A
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medchemexpress.com/trv-120027-tfa.htmlCatalog No: HY-P2141A
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
TRV120027 TFA, a ?-arrestin-1-biased agonist of the angiotensin II receptor type 1 AT1R , engages ?-arrestins while blocking G-protein signaling. TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 TRPC3 coupling, promotes the formation of a macromolecular complex composed of AT1RAAasAasAa?-arrestin-1AAasAasAaTRPC3AAasAasAaPLC? at the plasma membrane. TRV120027 TFA inhibits angiotensin IIAAasAasAamediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure ADHF treatment.
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