GENERAL CATALOGUE
TRV055
HY-P3136 · 5 mg
MedChemExpress · Cat: HY-P3136
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Catalog No: HY-P3136
CAS No: 25849-90-5
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
TRV055 TRV120055 is a G protein-biased agonist of angiotensin II type 1 receptors AT1Rs . TRV120055 induces fibroblast proliferation, overexpression of collagen I and ?-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/G?q-mediated signaling pathways, upregulates TGF-?1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses 1
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