TrxR/EGFR-IN-1

Description

TrxR/EGFR-IN-1 Compound L1Au2 is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib HY-50895 -sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib HY-50895 -resistant lung cancer.