Trypsin/Lys-C complex protease (MS grade)

Description

Trypsin/Lys-C complex protease MS grade combines Trypsin and Lys-C, two recombinant proteases, to achieve efficient peptide bond hydrolysis. Trypsin specifically cleaves the C-terminal peptide bonds of arginine R and lysine K , while Lys-C specifically cleaves the C-terminal peptide bonds of lysine K . This combination overcomes issues such as the slower digestion rate of lysine and arginine by rTrypsin, PTM changes on lysine, or hydrophobic C-termini such as proline that can lead to missed cleavage. Trypsin/Lys-C complex protease MS grade can be used to process complex protein samples that are difficult to enzymatically digest. Trypsin/Lys-C complex protease MS grade can be used for protein characterization, single-cell proteomics and large cohort proteomics studies.