GENERAL CATALOGUE
Tryptophan-cholic acid
HY-N15721 · 5 mg
MedChemExpress · Cat: HY-N15721
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Catalog No: HY-N15721
CAS No: 1630745-39-9
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
Tryptophan-cholic acid Trp-CA is a microbial amino-acid-conjugated bile acid, serving as an endogenous ligand and agonist of the orphan G protein-coupled receptor GPCR MRGPRE. Tryptophan-cholic acid activates MRGPRE, promoting the secretion of glucagon-like peptide-1 GLP-1 through the Gs-cAMP and ?-arrestin-1-ALDOA signaling pathways, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid is promising for research of type 2 diabetes.
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