GENERAL CATALOGUE
TSI-01
HY-112825 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-112825
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Catalog No: HY-112825
CAS No: 704878-75-1
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase lyso-PAFAT in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase LPCAT 1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 IC50s=0.47 versus 3.02 ?M for human LPCAT2 and LPCAT1, respectively . 60 ?M it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
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