Tubulin-IN-51

Description

Tubulin-IN-51 is an orally available, potent tubulin inhibitor IC50 = 31 nM . Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel HY-B0015 for binding. Tubulin-IN-51 inhibits the binding of Vinblastine HY-13780 to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis. Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models.