Tubulin/MMP-IN-3

Description

Tubulin/MMP-IN-3 Compound 15j is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 ?M and 19.24 ?M. Tubulin/MMP-IN-3 inhibits NF-?B signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models.