GENERAL CATALOGUE
Tubulin polymerization-IN-62
HY-161641 · 50 mg
MedChemExpress · Cat: HY-161641
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Catalog No: HY-161641
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
Tubulin polymerization-IN-62 Compound 14b is an inhibitor for microtubule polymerization IC50 is 7.5 ?M and a degrader for ?- and ?-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC50 of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate TGI of 74.27 % in 4T1 homograft mouse model.