Tubulin polymerization-IN-79

Description

Tubulin polymerization-IN-79 Compound C20 is a tubulin polymerization inhibitor. Tubulin polymerization-IN-79 shows potent antiproliferative activity against esophageal cancer cells e.g., KYSE450, IC50=0.36 ?M; EC-109, IC50=0.63 ?M . Tubulin polymerization-IN-79 occupies the colchicine binding site to disrupt microtubule network integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP expression, and inducing G2/M phase arrest and apoptosis in esophageal cancer cells. Tubulin polymerization-IN-79 is promising for research of esophageal cancers.