GENERAL CATALOGUE
Tuspetinib dihydrochloride
HY-145015B · 50 mg
MedChemExpress · Cat: HY-145015B
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Manufacturer product page
medchemexpress.com/tuspetinib-dihydrochloride.htmlCatalog No: HY-145015B
CAS No: 3037216-20-6
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Tuspetinib HM43239 dihydrochloride is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication ITD and FLT3 D835Y kinases, respectively. Tuspetinib dihydrochloride inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation and induces the apoptosis of leukemic cells.
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