GENERAL CATALOGUE
Tuspetinib
HY-145015 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-145015
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medchemexpress.com/tuspetinib.html
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Catalog No: HY-145015
CAS No: 2294874-49-8
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Tuspetinib HM43239 is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication ITD and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells.
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