GENERAL CATALOGUE
TW9
HY-155222 · 1 mg
MedChemExpress · Cat: HY-155222
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Catalog No: HY-155222
CAS No: 2614417-90-0
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
TW9 is a potent dual inhibitor simultaneously targeting BET and HDAC proteins with KDs of 0.069 ?M, 0.231 ?M for BRD4 1 , BRD4 2 , and an IC50 of 0.29 ?M for HDAC1, respectively. TW9 is a newly generated adduct of the BET inhibitor + -JQ1 HY-13030 and class I HDAC inhibitor CI994 HY-50934 . TW9 shows high potency in suppressing tumor growth in pancreatic ductal adenocarcinoma PDAC . TW9 improves the efficacy of the chemotherapeutic agent Gemcitabine HY-17026 .
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