TYRO3, His, Human

Description

The TAM receptors Tyro3, Axl and MerTK are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the eat-me signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.