U1C Rabbit Monoclonal Antibody

Description

EnkiLife offers the U1C Rabbit Monoclonal Antibody. This antibody reacts with Human,Rat species and is suitable for WB,IHC,ICC/IF,IP application. Alternative Names of Immunogen: U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,IP 1:20-1:50 Background: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Research Area: Epigenetics and Nuclear Signaling