GENERAL CATALOGUE
UBX-382
HY-160142 · 5 mg
MedChemExpress · Cat: HY-160142
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medchemexpress.com/ubx-382.htmlCatalog No: HY-160142
CAS No: 2884554-45-2
Category: MAPK ERK Pathway
Pack Size: 5 mg
Brand: MedChemExpress
Description
UBX-382 is an orally active BTK PROTAC degrader with a DC50 of 4.56 nM. UBX-382 inhibits B-cell receptor signaling by targeting BTK. UBX-382 shows superior degradation activity for wild-type and mutant BTK proteins. UBX-382 inhibits tumor growth in murine xenograft models harboring wild-type or C481S mutant BTK-expressing TMD-8 cells. UBX-382 can be used for the study of B-cell-related blood cancers.
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