GENERAL CATALOGUE
UCCF-029 free base
HY-128131 · 50 mg
MedChemExpress · Cat: HY-128131
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medchemexpress.com/uccf-029-free-base.htmlCatalog No: HY-128131
CAS No: 2110-25-0
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
UCCF-029 Free base is a potent activator of the cystic fibrosis transmembrane conductance regulator CFTR chloride channel. UCCF-029 Free base exhibits enhanced activity through benzannulation of the flavone A-ring at the 7,8-position. UCCF-029 Free base serves as a structural guide for the development of more effective flavonoid analogues. UCCF-029 Free base demonstrates improved potency compared to apigenin in activating wild-type CFTR. UCCF-029 Free base also exhibits potential for activating the mutant CFTR G551D-CFTR though not as robustly as apigenin.
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