

HY-119799 · 50 mg
MedChemExpress · Cat: HY-119799
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medchemexpress.com/uk-500001.htmlDescription
UK-500001 is an orally active inhibitor for phosphodiesterase 4 PDE4 , which inhibits PDE4D3 IC50 is 0.28 nM , PDE4B2 IC50 is 22.8 nM , PDE4A4 IC50 is 26.1 nM and PDE4C2 IC50 is 271 nM . UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-? and IFN-? release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease COPD and asthma.







