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UK-500001
GENERAL CATALOGUE

UK-500001

HY-119799 · 50 mg

MedChemExpress · Cat: HY-119799

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Catalog No: HY-119799
CAS No: 582332-31-8
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress

Description

UK-500001 is an orally active inhibitor for phosphodiesterase 4 PDE4 , which inhibits PDE4D3 IC50 is 0.28 nM , PDE4B2 IC50 is 22.8 nM , PDE4A4 IC50 is 26.1 nM and PDE4C2 IC50 is 271 nM . UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-? and IFN-? release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease COPD and asthma.

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