UNC1062

Description

UNC1062 is a highly selective tyrosine kinase MERTK inhibitor with an IC50 of 1.1 nM Morrison Ki = 0.33 nM . UNC1062 exhibits good selectivity for the TAM family TYRO3 IC50 = 60 nM, AXL IC50 = 85 nM . UNC1062 exhibits significant anti-proliferative effects and induces apoptosis in various cancer models such as melanoma, gastric cancer, and acute myeloid leukemia . UNC1062 inhibits multiple pathways, including MAPK/ERK, PI3K/AKT and JAK/STAT and affects the motility of head and neck squamous cell carcinoma HNSCC cells through the RhoA signaling pathway. UNC1062 inhibits macrophage efferocytosis, and it suitable for research on atherosclerosis.