GENERAL CATALOGUE
UNC9995
HY-120920 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-120920
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Catalog No: HY-120920
CAS No: 1354030-52-6
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
UNC9995 is a ?-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing ?-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/?-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions.
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