Upacicalcet

Description

Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist EC50 = 10.8 nM . Upacicalcet reduces serum intact parathyroid hormone iPTH and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine HY-B0152 -induced secondary hyperparathyroidism SHPT rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease CKD . Upacicalcet is useful for studying SHPT.